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. 2018 Jul 31;9:1763. doi: 10.3389/fimmu.2018.01763

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Copyright © 2018 Homan and Bremel.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Example of peptides of Opisthorchis viverrini and Ascaris lumbricoides, which have shared T-cell-exposed motifs (TCEMs) but in the context of differing groove-exposed motifs. X-axis of cell plot indicates multiple different major histocompatibility complex (MHC) II DRB alleles. Coloration of the cell plot indicates predicted binding affinity in standard deviation units below the mean for that protein. Blue indicates high binding affinity; red indicates low affinity. The peptides represent a range of suppressive indices: O. viverrini ranges from 621,829 to 20,788 and A. lumbricoides from 371,273 to 36,698 based on binding to all MHC II alleles evaluated. As the TCEM motif SL~L~LV is a common motif (FC3), these are all relatively high indices.