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. 2018 Jul 31;8:290. doi: 10.3389/fonc.2018.00290

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Copyright © 2018 Hu, Chen, Meng, Yu, He and Li.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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XPC overexpression increased cell apoptosis in the presence of IR or cisplatin. The apoptotic effect of IR and cisplatin on pcDNA3-XPC transfected cells and XPC silenced cells. Quantitative data are shown for annexin V-stained pcDNA3-XPC transfected cells and XPC silenced cells after treatment with cisplatin at different concentrations (A,B) and IR at different intensities for 4 h (C,D). The percentage of apoptotic pcDNA3-XPC transfected cells was significantly higher than in normal cells (*P < 0.01) and XPC silenced cells (*P < 0.01).