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. 2018 Jul 31;12:47. doi: 10.3389/fninf.2018.00047

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At least a portion of this work is authored by David M. Lovinger on behalf of the U.S. Government and, as regards Dr. Lovinger and the US government, is not subject to copyright protection in the United States. Foreign and other copyrights may apply.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Compensation and other correlations among channel conductances for SP neurons. (A–C) An increase in potassium channel conductance is compensated by an increase in inward channel conductance (sodium or calcium channels). (D) An increase in fast transient (KA_F) potassium channel conductance is compensated by a decrease in slow transient (KA_S) potassium channel conductance in in the soma. (E,F) Two non-compensatory correlations between channel conductances. (E) An increase in the fast sodium current in the soma is associated with an increase in the R type calcium channel (CaR) conductance. (F) An increase in delayed rectifier potasium channel is correlated with a decrease in N type calcium current in the soma. R is the Pearson's R correlation; all illustrated correlations are significant at P < 0.0001. Symbols corresponding to different neurons are the same in all panels and indicated in E.