Table 3.

Characteristics of optimization simulations.

	SP	GPe
Number of compartments	189	41
Number of experimental traces used	4	3
Duration of trace	0.9 s	2 s
Simulation time*	12.4 ± 1.03 h per 1,000 models	8.5 ± 0.16 h per 1,000 models
Evaluations to convergence#	2,100 ± 500	3,514 ± 1,007
Evaluations till fitness value is within 5% of minimum	867 ± 1,185	2,482 ± 1,133

^*Reported simulation time (mean and standard deviation) is for the second simulation seed.

^#Evaluations to convergence (mean and standard deviation) is for the second simulation seed; one of the GP simulations did not reach convergence within 5,000 model evaluations, yet reached a minimum fitness of 0.26.