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AAV.SGSHv4 Improves Behavioral Deficits in MPS IIIA Mice
Mice (8 wk old) were injected with AAV.SGSH or AAV.SGSH into lateral ventricle and animals tested in the Morris water maze 12 weeks later. (A) Latency to find the platform. (B) Time spent in the target quadrant on day 6. (C) Distance traveled in target quadrant on day 6. n = 14 for all groups. Data are mean ± SD. *p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001. One-way ANOVA followed by Tukey’s post hoc test.
