Figure 4.
Therapeutic Efficacy of NDV Is Dependent on CD8+ Cells and NK Cells but Not CD4+ Lymphocytes
Mice immunized and treated with NDV were depleted for CD4 or CD8 lymphocytes (B and C) or NK cells (D and E). (A) Treatment scheme. Tumors were established by implantation of 2 × 105 B16-F10 cells in the right flank. (B) Individual tumor growth curves after CD4 or CD8 depletion. (C) Overall survival after CD4 or CD8 depletion. (D) Individual tumor growth curves after NK depletion. (E) Overall survival after NK depletion. (B and C) Data represent cumulative results from two experiments with n = 10 (PBS), n = 19 (NDV + aCD4), and n = 19 (NDV + aCD8). (D and E) Data represent results of one experiment with n = 5 (PBS and PBS + aNK groups) and n = 10 (NDV and NDV + aNK groups). R, right; IP; intraperitoneal.