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Retinal vascular development in normal (WT) (a) and Dll4-deficient heterozygous mice (Dll4+/−) (b) at P6. Heterozygous Dll4 deletion causes severe developmental retinal vascular abnormalities leading to the increased blood vessel sprouting and formation of a syncytium-like vascular plexus (yellow arrowheads). 4x magnification. GS lectin staining. [33].
