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. 2018 Jul 4;10(8):e8613. doi: 10.15252/emmm.201708613

Figure EV4. Sex‐specific involvement of Cited4 insulin sensitization upon therapeutic rosiglitazone treatment.

Figure EV4

  • A, B
    Serum insulin concentration 60 min after glucose injection in the GTT in mice after 11 weeks of HFD and 4 weeks of HFD + Rosi. t‐test Cited4 −/− vs. Cited4 +/+, (A) n = 8, (B) n = 7/8.
  • C
    Blood glucose during insulin tolerance test (ITT) with 1 U insulin per kg lean mass on female mice after 11 weeks of HFD and 4 weeks of HFD + Rosi, expressed as % of the 0‐time point value (n = 8). *P = 0.015 (45 min), *P = 0.039 (60 min), *P = 0.035 (120 min) in repeated‐measures 2 × 2 ANOVA with Holm–Sidak posttests; Inlet: AUC t‐test Cited4 −/− vs. Cited4 +/+ *P = 0.041.
  • D
    Blood glucose during ITT on male mice as in (C) (n = 7/8). Repeated‐measures 2 × 2 ANOVA with Holm–Sidak posttests; Inlet: AUC t‐test.
Data information: Data are presented as mean ± SEM.