Table 4.
The 50 Most Upregulated mRNAs in High PARP and Platinum Sensitive OC Patient Samples in Comparison to low PARP and Platinum Resistant Samples.
| Gene name | Gene description | log2-fold change | p-value | q-value |
|---|---|---|---|---|
| COLEC11 | collectin subfamily member 11 | 3.68E+ 00 | 1.29E-02 | 0.2588936 |
| MYCN | MYCN proto-oncogene. bHLH transcription factor | 3.61E+ 00 | 2.74E-04 | 0.1050305 |
| ESM1 | endothelial cell specific molecule 1 | 3.18E+ 00 | 1.64E-04 | 0.1028588 |
| IGF1R | insulin like growth factor 1 receptor | 3.08E+ 00 | 5.29E-03 | 0.211962 |
| TNNC1 | troponin C1. slow skeletal and cardiac type | 3.04E+ 00 | 1.25E-05 | 0.0472319 |
| LGSN | lengsin. Lens protein with glutamine synthetase domain | 3.02E+ 00 | 1.25E-02 | 0.2588936 |
| LOC100134423 | uncharacterized LOC100134423 | 2.97E+ 00 | 2.71E-04 | 0.1050305 |
| DLK1 | delta like non-canonical Notch ligand 1 | 2.89E+ 00 | 4.17E-03 | 0.2013983 |
| CRYGC | crystallin gamma C | 2.86E+ 00 | 2.37E-03 | 0.1822358 |
| A_33_P3286709 | NA | 2.82E+ 00 | 9.15E-05 | 0.0864965 |
| PLEKHG4B | pleckstrin homology and RhoGEF domain containing G4B | 2.82E+ 00 | 1.17E-03 | 0.1525447 |
| TSPAN8 | tetraspanin 8 | 2.78E+ 00 | 2.99E-02 | 0.3064189 |
| ENPP6 | ectonucleotide pyrophosphatase/phosphodiesterase 6 | 2.73E+ 00 | 1.20E-02 | 0.2563874 |
| FLJ30901 | uncharacterized protein FLJ30901 | 2.60E+ 00 | 3.26E-04 | 0.1050305 |
| PROM1 | prominin 1 | 2.59E+ 00 | 3.02E-02 | 0.3079072 |
| COL22A1 | collagen type XXII alpha 1 chain | 2.58E+ 00 | 2.64E-03 | 0.1844765 |
| KIAA1324 | KIAA1324 | 2.58E+ 00 | 5.48E-04 | 0.1261184 |
| PTCH2 | patched 2 | 2.57E+ 00 | 1.93E-05 | 0.0472319 |
| SLC35F3 | solute carrier family 35 member F3 | 2.54E+ 00 | 3.87E-05 | 0.0596903 |
| GABRG3 | gamma-aminobutyric acid type A receptor gamma3 subunit | 2.51E+ 00 | 4.50E-05 | 0.0628517 |
| LOC613266 | uncharacterized LOC613266 | 2.50E+ 00 | 4.89E-02 | 0.3485897 |
| LCE1E | late cornified envelope 1E | 2.49E+ 00 | 2.28E-04 | 0.1050305 |
| B4GALNT4 | beta-1.4-N-acetyl-galactosaminyltransferase 4 | 2.49E+ 00 | 1.24E-05 | 0.0472319 |
| STC2 | stanniocalcin 2 | 2.48E+ 00 | 2.86E-04 | 0.1050305 |
| FOXL2NB | FOXL2 neighbor | 2.48E+ 00 | 1.04E-01 | 0.4447586 |
| AK124496 | NA | 2.47E+ 00 | 2.78E-02 | 0.3020977 |
| CU677518 | NA | 2.47E+ 00 | 2.82E-06 | 0.0275612 |
| NM_130777 | NA | 2.45E+ 00 | 1.10E-02 | 0.2525629 |
| NR_102701 | NA | 2.43E+ 00 | 2.11E-03 | 0.1762016 |
| NSG1 | neuronal vesicle trafficking associated 1 | 2.43E+ 00 | 1.05E-03 | 0.1525447 |
| STAR | steroidogenic acute regulatory protein | 2.41E+ 00 | 5.08E-03 | 0.2110634 |
| MCTS2P | malignant T-cell amplified sequence 2. pseudogene | 2.40E+ 00 | 5.43E-03 | 0.2134259 |
| TRABD2A | TraB domain containing 2A | 2.36E+ 00 | 4.89E-03 | 0.2078187 |
| DEPTOR | DEP domain containing MTOR interacting protein | 2.35E+ 00 | 4.70E-04 | 0.125416 |
| CLEC4GP1 | C-type lectin domain family 4 member G pseudogene 1 | 2.35E+ 00 | 4.56E-03 | 0.2021535 |
| LINC01405 | long intergenic non-protein coding RNA 1405 | 2.33E+ 00 | 6.95E-04 | 0.1391319 |
| COL2A1 | collagen type II alpha 1 chain | 2.32E+ 00 | 1.82E-02 | 0.2816697 |
| HS6ST2 | heparan sulfate 6-O-sulfotransferase 2 | 2.31E+ 00 | 2.15E-02 | 0.2871745 |
| PRAME | preferentially expressed antigen in melanoma | 2.30E+ 00 | 4.32E-05 | 0.0628517 |
| LINC02398 | long intergenic non-protein coding RNA 2398 | 2.29E+ 00 | 1.08E-05 | 0.0472319 |
| GJB7 | gap junction protein beta 7 | 2.29E+ 00 | 3.18E-02 | 0.3122712 |
| PLCXD3 | phosphatidylinositol specific phospholipase C X domain containing 3 | 2.28E+ 00 | 6.03E-02 | 0.3707384 |
| ERVI-1 | endogenous retrovirus group I member 1 | 2.27E+ 00 | 1.28E-02 | 0.2588936 |
| ZNF556 | zinc finger protein 556 | 2.27E+ 00 | 1.46E-06 | 0.0213888 |
| NTS | neurotensin | 2.26E+ 00 | 6.56E-02 | 0.3828556 |
| BU963192 | NA | 2.25E+ 00 | 7.17E-05 | 0.0751488 |
| GMNC | geminin coiled-coil domain containing | 2.24E+ 00 | 1.52E-02 | 0.2689731 |
| A_33_P3274001 | NA | 2.24E+ 00 | 9.36E-05 | 0.0864965 |
| CRYGD | crystallin gamma D | 2.24E+ 00 | 2.58E-02 | 0.2964626 |
| GREB1 | growth regulation by estrogen in breast cancer 1 | 2.22E+ 00 | 1.22E-03 | 0.1542519 |
mRNAs selected for further validation are shown in bold.