Table 5.
The 50 Most Downregulated mRNAs in High PARP and Platinum Sensitive OC Patient Samples in Comparison to Low PARP and Platinum Resistant Samples
| Gene Name | Gene Description | Log2-Fold Change | p-Value | q-Value |
|---|---|---|---|---|
| EFEMP1 | EGF containing fibulin extracellular matrix protein 1 | −3.85E+ 00 | 1.50E-03 | 0.1587368 |
| FAP | fibroblast activation protein alpha | −3.66E+ 00 | 9.07E-04 | 0.1525447 |
| TMOD1 | tropomodulin 1 | −3.41E+ 00 | 2.92E-08 | 0.0008577 |
| BNC1 | basonuclin 1 | −3.36E+ 00 | 2.74E-04 | 0.1050305 |
| ENST00000453673 | NA | −3.22E+ 00 | 2.22E-02 | 0.2877726 |
| ENST00000411475 | NA | −3.18E+ 00 | 2.30E-02 | 0.2898232 |
| SCRG1 | stimulator of chondrogenesis 1 | −3.18E+ 00 | 1.64E-03 | 0.1627023 |
| PTGFR | prostaglandin F receptor | −3.04E+ 00 | 1.05E-03 | 0.1525447 |
| POSTN | periostin | −3.01E+ 00 | 1.10E-02 | 0.2525629 |
| ENST00000390237 | NA | −2.97E+ 00 | 1.54E-02 | 0.2695379 |
| BF175071 | NA | −2.92E+ 00 | 5.12E-02 | 0.3538495 |
| GUCY1A3 | guanylate cyclase 1 soluble subunit alpha | −2.89E+ 00 | 5.68E-05 | 0.0723946 |
| ENST00000390628 | NA | −2.87E+ 00 | 4.44E-03 | 0.2021325 |
| CXCL13 | C-X-C motif chemokine ligand 13 | −2.87E+ 00 | 1.02E-02 | 0.2487313 |
| ACKR4 | atypical chemokine receptor 4 | −2.86E+ 00 | 9.73E-05 | 0.0864965 |
| IGLL5 | immunoglobulin lambda like polypeptide 5 | −2.86E+ 00 | 3.46E-02 | 0.318167 |
| AREG | amphiregulin | −2.83E+ 00 | 1.43E-02 | 0.2670241 |
| A_33_P3251412 | NA | −2.81E+ 00 | 1.46E-02 | 0.2682963 |
| FYB1 | FYN binding protein 1 | −2.79E+ 00 | 2.51E-03 | 0.1843078 |
| CD38 | CD38 molecule | −2.78E+ 00 | 1.54E-03 | 0.1587368 |
| ENST00000468879 | NA | −2.77E+ 00 | 4.36E-02 | 0.3380632 |
| ENST00000390252 | NA | −2.73E+ 00 | 1.49E-02 | 0.2682963 |
| JCHAIN | joining chain of multimeric IgA and IgM | −2.70E+ 00 | 6.61E-03 | 0.2195342 |
| ENST00000390547 | NA | −2.69E+ 00 | 5.85E-03 | 0.2163421 |
| MEDAG | mesenteric estrogen dependent adipogenesis | −2.69E+ 00 | 4.49E-02 | 0.3403785 |
| CNR1 | cannabinoid receptor 1 | −2.68E+ 00 | 9.85E-03 | 0.2471112 |
| PRRX1 | paired related homeobox 1 | −2.68E+ 00 | 7.45E-04 | 0.1427284 |
| NR4A3 | nuclear receptor subfamily 4 group A member 3 | −2.67E+ 00 | 2.00E-02 | 0.2850432 |
| CH25H | cholesterol 25-hydroxylase | −2.65E+ 00 | 2.21E-03 | 0.1762175 |
| AB363267 | NA | −2.65E+ 00 | 4.23E-02 | 0.3347815 |
| ENST00000426099 | NA | −2.63E+ 00 | 4.11E-02 | 0.331398 |
| CCL18 | C-C motif chemokine ligand 18 | −2.57E+ 00 | 1.16E-04 | 0.0898927 |
| THBS2 | thrombospondin 2 | −2.57E+ 00 | 3.91E-02 | 0.327707 |
| ENST00000410078 | NA | −2.56E+ 00 | 5.30E-02 | 0.3580372 |
| BCHE | butyrylcholinesterase | −2.55E+ 00 | 1.00E-02 | 0.2471753 |
| ATP6V1D | ATPase H+ transporting V1 subunit D | −2.55E+ 00 | 1.54E-04 | 0.1028588 |
| ENST00000390323 | NA | −2.55E+ 00 | 2.42E-02 | 0.2937808 |
| CCR2 | C-C motif chemokine receptor 2 | −2.54E+ 00 | 9.37E-03 | 0.24523 |
| ENST00000479981 | NA | −2.54E+ 00 | 9.43E-03 | 0.24523 |
| CAST | calpastatin | −2.54E+ 00 | 1.02E-03 | 0.1525447 |
| ASPN | asporin | −2.52E+ 00 | 2.94E-02 | 0.3049408 |
| HBB | hemoglobin subunit beta | −2.52E+ 00 | 2.08E-02 | 0.2862875 |
| ENST00000390247 | NA | −2.51E+ 00 | 2.16E-02 | 0.2871745 |
| SULF1 | sulfatase 1 | −2.50E+ 00 | 1.80E-02 | 0.2805948 |
| EPYC | epiphycan | −2.49E+ 00 | 1.28E-02 | 0.2588936 |
| FGFBP1 | fibroblast growth factor binding protein 1 | −2.49E+ 00 | 1.03E-02 | 0.2499163 |
| LRRC15 | leucine rich repeat containing 15 | −2.48E+ 00 | 4.14E-02 | 0.3321649 |
| DOCK11 | dedicator of cytokinesis 11 | −2.45E+ 00 | 5.13E-04 | 0.1261184 |
| OOEP | oocyte expressed protein | −2.45E+ 00 | 4.23E-03 | 0.2013983 |
| ROR2 | receptor tyrosine kinase like orphan receptor 2 | −1.84E+ 00 | 2.83E-05 | 0.0506967 |
mRNAs selected for further validation are shown in bold.