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Decreased resistance to oxidative stress and shorter lifespan of MsrA−/−. (A) 16 WT and 16 MsrA−/− mice (4.5 months of age) were exposed to 100% oxygen (hyperoxia). (B) Shorter lifespan of MsrA−/− mice exposed to 20% oxygen (normoxia). Data were analyzed by using the cumulative survival (Kaplan and Meier method; ref. 14) of WT, MsrA−/−, and MsrA+/− mice.
