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. 2018 Jul 13;8(3):2045894018791557. doi: 10.1177/2045894018791557

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© The Author(s) 2018

Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Fig. 9. — Accelerated purine metabolism in adult asymptomatic SCD patients. Changes in urine adenosine (a) and inosine (b) levels and adenosine/inosine ratio (e) indicate increased extracellular ADA activity. Changes in inosine (b), hypoxanthine (c), guanosine (f) and guanine (g) levels indicate increased extracellular PNP activity. Hemolysis in SCD patient is associated with large production of vasculotoxic hypoxanthine (c) and xanthine (d). Reduced levels of endogenous PNP inhibitors 8-aminoguanosine (h) and 8-aminoguanine (i).