Table 6.
Major binding interactions of Alkaloids resulted by docking studies.
| Sr. No | Alkaloid compounds | H-Bond interaction | π-π Stacking | Software Utilized | Refs. |
|---|---|---|---|---|---|
| 1. | Morpholine derivatives | Tyr326 | _ | Autodock 4.0 | Lühr et al., (2010) [64] |
| 2. | Piperine | Tyr 188, Gln 206 Cys 172, Tyr 326, Thr 201 and Ileu 199 | _ | Schrödinger | Mu et al., (2012) [73] |
| 3. | Menadione (vitamin K3) | Tyr398 and Tyr435 (for MAO-A) Tyr407 and Tyr444 (for MAO-B) |
_ | AutoDock 4.0 | Cerqueira et al., (2011) [65] |
| 4. | Amphetamine | Tyr197 | Tyr407 | AutoDockVina | Fresqui et al., (2013) [78] |
| 5. | Quinazoline | GLN 74, ILE 207, and TYR 444 SER 209 and GLU 216 | _ | MOE-Dock | Khattab et al., (2015) [81] |
| 6. | Nicotinamide | Tyr 444, Asn181 and Tyr 197 | Tyr407 | AUTODOCKTOOLS (ADT) | Shi et al., (2010) [73] |
| 7. | Caffeine | Tyr444, Tyr435 | _ | Autodock 4.0 | Petzer et al., (2016) [34] |
| 8. | Psychotria alkaloids | WAT-746 | Tyr-407 | GOLD | Son et al., (2013) [29] |