Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 Jul 31;9:772. doi: 10.3389/fphar.2018.00772

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2018 Li, Gong, Jiang, Lin, Zhou, Zhang, Li, Zhang, Wan, Kuang and Li.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Fisetin reverses EMT in TNBC cells in vitro. TNBC cell lines MDA-MB-231 and BT549 were treated with vehicle or fisetin for 24 h. (A) The morphology of the cells treated with vehicle or 30 μM fisetin was observed by phase-contrast microscopy. (B) E-cadherin and (C) Vimentin and F-actin expression were evaluated by immunofluorescence in TNBC cells treated by vehicle or 30 μM fisetin. The cells pretreated with vehicle or various concentrations of fisetin (10, 30, and 100 μM, respectively) were subjected to western blot for the indicated proteins (D) and qRT-PCR for the indicated mRNA (E). The results are shown as the mean ± SD of three experiments, ^∗P < 0.05, ^∗∗P < 0.01 compared with control.