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. 2018 Jul 31;9:772. doi: 10.3389/fphar.2018.00772

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Copyright © 2018 Li, Gong, Jiang, Lin, Zhou, Zhang, Li, Zhang, Wan, Kuang and Li.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Fisetin inhibits the growth and metastasis of TNBC in vivo. Xenograft breast cancer model was established by subcutaneous injection of MDA-MB-231 cells in the presence or absence of fisetin (100 mg/kg). (A) Tumor growth curve was recorded. (B) Tumor weight was measured. (C) The expression of Ki67 in the primary tumor tissues was evaluated by immunohistochemistry staining. (D) Metastatic tumor nodules on the surface of lungs were counted. (E) Representative images of HE staining in the metastatic nodules of lungs. The results are shown as the mean ± SD of six experiments, ^∗P < 0.05, ^∗∗P < 0.01 compared with control.