Figure 5.

Positive Correlation between Anti-tumor Effects and IS Quality

(A) Correlation analysis between the quality of the IS and the killing efficiency (the reciprocal of area under the curve of tumor cell numbers). (B) Correlation analysis between the quality of the IS and the proliferation efficiency (the area under the curve of T cell numbers). The quality of the IS was measured by the intensities of F-actin, pZeta, and cluster of tumor antigen, as well as the percentage of perforin polarization. The Pearson r value was calculated. Each dot represents one donor. These data represent at least three independent experiments.