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. 2001 Nov 6;98(23):12932–12937. doi: 10.1073/pnas.231463798

Figure 3.

Figure 3

Active site residues in precursor galactose oxidase (Left) and in the mature protein (Center) showing the copper ligands (Tyr-272, Tyr-495, His-496, and His-581), Cys-228 that forms the thioether bond to Tyr-272, the tryptophan that stacks over it (Trp-290), and Phe-227. The Sγ of Cys-228 in the precursor is situated directly above Cɛ2 of Tyr-272. In the precursor the sulfur of the cysteine appears to have been oxidized to a sulfenic group. (Right) Final 2Fo − Fc electron density map for Cys-228 and Tyr-272.