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. Author manuscript; available in PMC: 2018 Aug 7.
Published in final edited form as: ACS Chem Biol. 2018 Jun 1;13(7):1799–1809. doi: 10.1021/acschembio.8b00347

Figure 5.

Figure 5.

DNA damage sensing by repair proteins containing [4Fe4S] clusters. (Top) DNA CT can occur between proteins when there is no intervening lesion. The charge effectively scans the DNA for lesions and, if the DNA integrity is conserved, the reduced protein will dissociate from the DNA allowing the repair protein to search for damage elsewhere. If there is an intervening lesion between proteins, the charge is unable to be transported, which allows the oxidized protein to stay in the vicinity of the damage and locate it more quickly. (Below) DNA-modified electrodes can be used to monitor helicase activity of DinG through the redox signal of its [4Fe4S] cluster in DinG, which becomes better coupled with ATP but not with ATPγS, with which there is no helicase activity.