Figure 6.

Growth and Neurobehavioral Outcomes in rAAV9-rsATP7A Plus sc Copper Histidinate-Treated mo-br Mice

(A) Weight gain in rAAV9 plus sc copper histidinate-treated mutant mice (blue line; n = 10 at start, n = 8 at end) was lower than in wild-type mice (red line; n = 21 at start, 18 at end), until 90–120 days of age, by which time “catch-up” growth was evident. Wire-hang (B) and rotarod (C) test results for mutant mice treated with rAAV9-rsATP7A plus sc copper histidinate combination treatment (blue; n = 10 at start, 8 at end) compared to wild-type (WT) male littermates (red). Error bars, SEM.