Table 2.
Changes in miRNA expression in diseased gingival tissues of periodontitis patients compared to healthy controls
| miRNAs | Changes in expression | References | Expression in cells* |
|---|---|---|---|
| miR-9 | Up | 16, 19 | Depleted in epithelial cell |
| miR-15a | Up | 20 | Enriched in leukocyte, haematopoietic cell, lymphocyte Depleted in epithelial cell, fibroblast |
| miR-17 | Up | 16, 19 | Enriched in epithelial cell, endothelial cell |
| miR-19a,b | Up | 16, 19 | Enriched in epithelial cell, endothelial cell, haematopoietic cell, leukocyte, monocyte Depleted in fibroblast |
| miR-21 | Up | 16 | Enriched in myeloid leukocyte, monocyte, phagocyte Depleted in neutrophil |
| miR-26 | Up | 16 | Enriched in haematopoietic cell, leukocyte Depleted in epithelial cell |
| miR-29a,b,c | Up | 16, 18, 19 | Enriched in haematopoietic cell, mononuclear cell, lymphocyte, lymphocyte Depleted in endothelial cell, epithelial cell, fibroblast |
| miR-30b,c,d | Up | 16, 19, 20 | Enriched in haematopoietic cell, leukocyte, epithelial cell Depleted in endothelial cell, fibroblast |
| miR-34a,c | Up | 16, 19 | Enriched in endothelial cell, epithelial cell Depleted in haematopoietic cell, leukocyte, lymphocyte |
| miR-125a | Up | 16, 19 | Enriched in haematopoietic cell, leukocyte Depleted in B cell, meso-epithelial cell |
| miR-125b | Up | 16, 19 | Enriched in fibroblast Depleted in haematopoietic cell, leukocyte, lymphocyte |
| miR-126 | Up | 18, 19 | Enriched in endothelial cell, meso-epithelial cell Depleted in ecto-epithelial cell |
| miR-142 | Up | 16, 19, 20 | Enriched in haematopoietic cell, leukocyte, lymphocyte Depleted in epithelial cell, fibroblast |
| miR-146a | Up | 19 | Enriched in haematopoietic cell, leukocyte, monocyte Depleted in endothelial cell |
| miR-148 | Up | 18 | Enriched in haematopoietic cell, leukocyte, monocyte Depleted in endothelial cell |
| miR-155 | Up | 18 | Enriched in haematopoietic cell, leukocyte, monocyte Depleted in endothelial cell |
| miR-181c | Up | 16, 19 | Enriched in haematopoietic cell, leukocyte |
| miR-223 | Up | 17, 18 | Enriched in haematopoietic cell, leukocyte Depleted in epithelial cell |
| miR-301 | Up | 16, 18 | Enriched in haematopoietic cell, leukocyte Depleted in epithelial cell |
| let-7b–e | Up | 16, 18 | Depleted in haematopoietic cell, leukocyte, lymphocyte |
| let-7f, g | Up | 16, 18 | Enriched in haematopoietic cell, leukocyte, lymphocyte |
| miR-31 | Down | 18 | Enriched in endothelial cell Depleted in haematopoietic cell, leukocyte |
| miR-92a | Down | 16 | Enriched in B cell, epithelial cell |
| miR-214 | Down | 16 | Enriched in fibroblast Depleted in haematopoietic cell, leukocyte, epithelial cell |
| miR-451 | Down | 16 | Enriched in haematopoietic cell, neutrophil, leukocyte Depleted in endothelial cell, epithelial cell |