FIGURE 2.

Diagrams of the known netrin-1 receptor dimers and their signaling functions. Netrin-1 binding simultaneously to two DCC molecules induces DCC homodimers, which similarly occurs for neogenin. If netrin is substrate bound, this could crosslink DCC dimers to the extracellular matrix. However, the signaling result of neogenin dimers is not currently known. Whether netrin-1 also links neogenin:neogenin, UNC5:DCC, or UNC5:DSCAM dimers to the extracellular matrix is also unknown, but represents potential mechanotransductive mechanisms in netrin-1 signaling. Structural studies have not been conducted on the UNC5:DSCAM dimer, therefore whether a single netrin-1 molecule binds both receptors is unknown.