FIGURE 7.

Summary of known signaling pathways downstream of UNC5 in repulsive netrin-1 signaling. Interaction between the intracellular DB domain of UNC5 and the P1 domain of DCC produces a scaffold similar to that in DCC homodimers. FAK and Src are phosphorylated and activated as in attractive netrin-1 signaling, however, the functional outcomes are different. CDC42, cell division control protein 42; CRMP, collapsin response mediating protein; DB, DCC-binding domain; DD, death domain; FAK, focal adhesion kinase; FMOs, Flavin monooxygenases; Ig, immunoglobulin domain; MAX2, more axillary growth 2; PLEKHH1, pleckstrin homology MyTH and FERM domain containing protein H1; RAC1, Ras-related C3 botulinum toxin substrate 1; RHOA, Ras homolog gene family member A; SHP2, protein tyrosine phosphatase 2C; SRC, proto-oncogene tyrosine-protein kinase Src; TRIO, triple domain functional protein; TSP, thrombospondin type 1 domain; ZU5, ZO-1/Unc5 domain.