FIGURE 1.

Male and female DAGLα^−/− mice have impaired fear extinction. (A) Schematic diagram of the experimental paradigm. (B) (Far left panel) % freezing by male DAGLα^−/− and WT mice during acquisition of cue-conditioned fear. (Middle panels) % freezing during auditory cue during extinction training days 2 and 3. (Far right panel) % freezing during extinction recall (n = 5 WT, n = 4 KO mice). (C) (Far left panel) % freezing by female DAGLα^−/− and WT mice during acquisition of cue-conditioned fear. (Middle panels) % freezing during auditory cue during extinction training days 2 and 3. (Far right panel) % freezing during extinction recall (n = 5 WT, n = 4 KO mice). F- and P-values and η² for genotype effect shown in each panel. All values are presented as mean ± SEM.