FIGURE 5.

AEA augmentation does not reverse impaired extinction after DAGL inhibition. (A) Schematic diagram of the experimental paradigm. (B) (Far left panel) % freezing by C57BL/6J male mice during acquisition of cue-conditioned fear. (Middle panels) % freezing during auditory cue by mice during extinction training days 2 and 3 when DO34 (50 mg kg⁻¹) was injected alone or in addition to PF-3845 (FAHH inhibitor 1 mg kg⁻¹) IP 2 h prior to trial. (Far right panel) % freezing during extinction recall (n = 18 male mice per condition). F- and P-values and η² for main effect of drug shown in each panel. All values are presented as mean ± SEM.