Table 3.

Values of NSAID concentrations (M) required to obtain 25% of fluidizing effect (FE₂₅) in the lipid nanocarriers MLVs of EPC (500 μM, pH 7.4) labeled with n-AS probes.

Drug	2-AS	6-AS	9-AS	12-AS
Tolmetin	0.4112 ± 0.0001122	0.3955 ± 0.0001582	0.3633 ± 0.0001453	0.2272 ± 0.00009089
Acemetacin	0.1492 ± 0.0005921****	0.1346 ± 0.0005386*	0.0879 ± 0.0003514****	0.0459 ± 0.0001838****
Indomethacin	0.1684 ± 0.0005567*	0.1255 ± 0.0005021****	0.0953 ± 0.0003812*	0.0532 ± 0.0002129*

The values of FE₂₅ correspond to the mean and respective standard deviation obtained for at least three independent assays. Comparisons were performed using a Krauskal-Wallis test followed by Dunn's Post-hoc test for the following paired observations: FE₂₅ values of Tolmetin vs. FE₂₅ values of Acemetacin and Indomethacin.

^****P < 0.0001,

^*P < 0.05.