Table 4.

Binding constant (K_b) and number of binding locations (n) of Clonixin and DSPC:DODAP (2:1) loaded with 15% of Clonixin to HSA.

	K${}_{\mathrm{\text{b}}}^{\mathrm{\text{§}}}$	n	R2
Clonixin	111 ± 10	1 ± 0.008	0.999
DSPC:DODAP (2:1) + 15% Clonixin	143 ± 39****	1 ± 0.052ns	0.938

^§(x10⁻²) M⁻¹.

The values of K_b and n correspond to the mean and respective standard deviation obtained for at least three independent assays. Comparisons were performed using non-parametric Mann-Whitney test, comparing cumulative distributions between Formulation + 15% drug vs. drug.

^****P < 0.0001;

^ns, not significant.