Table 2.

Treatment outcomes (per protocol analysis) by epidemiological strata, Madagascar 2012–2016, ASAQ

Epidemiological strata	Eastern Madagascar (equatorial stratum)
Site	Matanga		Tsaratanana
District	Vangaindrano		Ifanadiana
Year	2012		2016
Number of patients, n	64		67
Clinical outcomes	Unadjusted-PCR	PCR-corrected	Unadjusted-PCR	PCR-corrected
ETF, n	0	0	0	0
LCT, n	0	0	0	0
LPF, n	2	1	0	0
ACPR, n (%)	62 (96.9)	62 (98.4)	65 (100)	65 (100)
CI 95% (%)	89.3–99.1	91.5–99.7	94.4–100	94.4–100
Withdrawal, n	0	1	2a	2a
Lost to follow-up, n	0	0	0	0

Epidemiological strata	Fringe highlands of Madagascar (fringe highlands stratum)
Site	Ampasipotsy		Anjoma Ramartina
District	Tsiroanomandidy		Mandoto
Year	2012		2013
Number of patients, n	44		60
Clinical outcomes	Unadjusted-PCR	PCR corrected	Unadjusted-PCR	PCR corrected
ETF	0	0	0	0
LCT	1	0	0	0
LPF	0	0	0	0
ACPR	39 (97.5)	39 (100)	53 (100)	53 (100)
CI 95% (%)	87.1–99.6	91–100	93.2–100	93.2–100
Withdrawal, n	0	1	0	0
Lost to follow-up, n	4	4	7	7

Epidemiological strata	Western Madagascar (tropical stratum)
Site	Ankazomborona		Antanimbary
District	Marovoay		Maevatanana
Year	2013		2016
Number of patients, n	63		50
Clinical outcomes	Unadjusted-PCR	PCR corrected	Unadjusted-PCR	PCR corrected
ETF	0	0	0	0
LCT	0	0	0	0
LPF	0	0	0	0
ACPR	63 (100)	63 (100)	46 (100)	46 (100)
CI 95% (%)	94.3–100	94.3–100	92.3–100	92.3–100
Withdrawal, n	0	0	0	0
Lost to follow-up, n	0	0	4	4

ETF early therapeutic failure, LCF late clinical failure, LPF late parasitological failure, ACPR adequate clinical and parasitological response

^aWithdrawal of consent