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Single-cell simulations using various myocardial cell types under the WT and S140G mutation conditions. IKs currents (A–C), the corresponding AP shapes (D–F), and APDR curves (G–L) under the WT and KCNQ1 S140G mutation conditions in ventricular endocardium (Endo), mid-myocardium (M), and epicardium (Epi) cells. APD, action potential duration; DI, diastolic interval and; BCL, basic cycle length.
