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Downregulated expression of miR-646 and upregulated expression of IGF-1 in hypoxia conditions. (A) The downregulation of miR646 mRNA in hypoxia conditions was analyzed by RT-qPCR (** P<0.01, * P=0.02). (B) The upregulation of IGF-1 mRNA in hypoxia conditions was analyzed by RT-qPCR (** P<0.01, * P=0.03). (C) The results of western blot shown IGF-1 protein expression was significantly increased.
