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. 2018 Jul 30;24:5282–5291. doi: 10.12659/MSM.910163

Figure 4.

Figure 4

MiR-646 promote apoptosis of hPDLCs in hypoxia conditions. The relative caspase-3 activity was decreased with miR-646 downregulation and increased with miR-646 overexpression in (A) 21% O2 condition (* P=0.03 pre-miR-646 vs. pre-miR-Ctrl, * P=0.02 anti-miR-646 vs. anti-miR-Ctrl); (B) 5% O2 condition (* P=0.03 pre-miR-646 vs. pre-miR-Ctrl, * P=0.02 anti-miR-646 vs. anti-miR-Ctrl); and (C) 1% O2 condition (* P<0.01 pre-miR-646 vs. pre-miR-Ctrl, * P=0.02 anti-miR-646 vs. anti-miR-Ctrl). The results of flow cytometry analysis results were consistent with the caspase-3 ELISA assay.