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. 2018 Jun 5;2:PO.18.00055. doi: 10.1200/PO.18.00055

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© 2018 by American Society of Clinical Oncology

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Fig 1. — Clinical tumor and KIT mutation analysis. (A) Representative brain magnetic resonance images show left frontal operculum metastasis with perilesional edema pretreatment (top panel) and the on-treatment combination dasatinib and crizotinib therapy effect (lower panel). (B) Polymerase chain reaction–based DNA sequencing chromatogram showing a KIT nucleotide transition (2464 A>T) at codon 822 (AAT to TAT) in exon 17 from the patient’s acral melanoma metastatic tumor. (C) Hematoxylin and eosin (HE) and immunohistochemical staining for total KIT and phosphorylated KIT (p936) and total MET in the patient’s primary (upper panel) and metastatic (lower panel) acral melanoma tumors (original magnification, ×20).