Table 2.
Multivariable Cox Regression Analysis in the Training Cohort
| Variables | Overall Survival |
Disease-Free Survival |
||
|---|---|---|---|---|
| HR (95% CI) | p value | HR (95% CI) | P Value | |
| CEA(ng/ml) (elevated vs. normal) | 2.070 (1.285-3.336) | 0.003 | 2.403 (1.531-3.771) | 0.001 |
| Depth of invasion | 0.093 | 0.031 | ||
| T4b | Reference | Reference | ||
| T1 | 0.001(0.0001-999) | 0.962 | 0.001(0.0001-999) | 0.959 |
| T2 | 0.343 (0.132-0.894) | 0.029 | 0.310 (0.125-0.769) | 0.012 |
| T3 | 0.463 (0.257-0.836) | 0.011 | 0.388 (0.214-0.702) | 0.002 |
| T4a | 0.859 (0.422-1.750) | 0.676 | 0.648 (0.325-1.290) | 0.217 |
| Lymph node metastasis | 0.012 | 0.012 | ||
| N0 | Reference | Reference | ||
| N1 | 1.736 (1.074-2.808) | 0.024 | 1.736 (1.074-2.808) | 0.024 |
| N2 | 2.287 (1.263-4.142) | 0.006 | 2.287 (1.263-4.142) | 0.006 |
| Metastasis (M1 vs. M0) | 2.739 (1.532-4.895) | 0.001 | 2.739 (1.532-4.895) | 0.001 |
| CSN2 (high vs. low) | 0.546 (0.354-0.842) | 0.006 | 0.624 (0.410-0.949) | 0.027 |
| CD8 (high vs. low) | 0.627 (0.396-0.993) | 0.047 | 0.574 (0.372-0.886) | 0.012 |
| MMR status (pMMR vs. dMMR) | 4.065 (1.415-11.677) | 0.009 | 3.580 (1.376-9.310) | 0.009 |
CEA: carcinoembryonic antigen.