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Incidence of Treatment-Related Toxicities for Each Dose Cohort
| Adverse Events | No. of Patients (All Grades) |
||||
|---|---|---|---|---|---|
| Cohort 1 | Cohort 2 | Cohort 3 | Cohort 4 | Total (%) | |
| Hypertension | 1 | 1 | 1 | 1 | 4 (33.3) |
| HFS | 1 | 2 | 0 | 1 | 4 (33.3) |
| Proteinuria | 0 | 2 | 0 | 1 | 3 (25.0) |
| Nausea | 1 | 1 | 0 | 1 | 3 (25.0) |
| Neutropenia | 0 | 1 | 1 | 1 | 3 (25.0) |
| Fatigue | 1 | 1 | 2 | 1 | 5 (41.6) |
| Hyperbilirubinemia | 1 | 0 | 0 | 0 | 1 (8.3) |
| Diarrhea | 0 | 1 | 0 | 0 | 1 (8.3) |
| Thrombocytopenia | 0 | 0 | 0 | 1 | 1 (8.3) |
HFS, hand-foot syndrome.
