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. 2018 Jul 1;29(13):1640–1651. doi: 10.1091/mbc.E17-09-0546

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© 2018 Zhao et al. “ASCB®,” “The American Society for Cell Biology®,” and “Molecular Biology of the Cell®” are registered trademarks of The American Society for Cell Biology.

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FIGURE 5: — Model of Vha68-1 function in Rh1 trafficking. In wild-type flies, Rh1 is synthesized in the ER and undergoes N-glycosylation. Oligosaccharides are sequentially removed in the Golgi and secretory vesicles before mature Rh1 is delivered to the rhabdomere. In vha68-1¹ mutant flies, post-Golgi secretory vesicles fail to maintain low pH level because of V-ATPase malfunction. As a result, Rh1 is not fully deglycosylated, accumulating in secretory vesicles within the photoreceptor cell body. Levels of functional Rh1 are therefore reduced in the rhabdomere.