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. Author manuscript; available in PMC: 2018 Aug 7.
Published in final edited form as: Bioconjug Chem. 2017 Apr 26;28(5):1529–1536. doi: 10.1021/acs.bioconjchem.7b00169

Scheme 1. Synthesis of VUTP 3a.

Scheme 1

a(a) Pd2(dba)3, P(Fur)3, vinyltributylstannane, DMF, 60 °C, 3 h, 53%. (b) (i) POCl3, proton sponge, trimethylphosphate, ~4 °C, 30 min and (ii) bis-tributylammonium pyrophosphate, tributylamine, ~4 °C, 30 min, 21%.