Table 2. Duration of sedation and doses of sedative and analgesic agents according to development of delirium.
All patients n = 252 |
No-delirium n = 67 (27%) |
Delirium n = 185 (73%) |
p-value | |
---|---|---|---|---|
ICU parameters (median [interquartile range]) | ||||
Duration of mechanical ventilation, days | 7 (4, 18) | 5 (2, 9) | 8 (4, 22) | 0.001 |
Duration of sedation, days | 6 (3, 12) | 4 (2, 7) | 7 (4, 13) | 0.001 |
Maximum dose of midazolam in the first five days, mg/hour | 3.4 (0, 5.4) | 2 (0, 5.8) | 3.6 (0.8, 5.4) | 0.084 |
Maximum dose of propofol in the first five days, mg/hour | 1 (1, 3.2) | 0.8 (1, 3.1) | 1 (1, 3.2) | 0.866 |
Maximum dose of fentanyl in the first five days, mg/hour | 1.6 (0, 2.4) | 1.2 (0, 2.4) | 1.6 (0, 2.4) | 0.516 |
Maximum dose of morphine in the first five days, mg/hour | 1 (0.5, 1.5) | 1 (1, 1.5) | 0.5 (0. 6,1) | 0.044 |
Maximum dose of remifentanil in the first five days, mg/hour | 0.1 (0, 0.2) | 0.07 (0, 0.2) | 0.1 (0, 0.2) | 0.081 |
Maximum dose of dobutamine in the first five days, μg/kg/min | 2.2 (0, 5.3) | 1.4 (0, 8) | 2.8 (0, 5.8) | 0.038 |
Maximum dose of norepinephrine in the first five days, μg/kg/min | 0.1 (0, 0.21) | 0.07 (0, 0.15) | 0.1 (0, 0.22) | 0.01 |