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. 2018 Aug 7;13(8):e0200495. doi: 10.1371/journal.pone.0200495

Table 2. Duration of sedation and doses of sedative and analgesic agents according to development of delirium.

All patients
n = 252
No-delirium
n = 67 (27%)
Delirium
n = 185 (73%)
p-value
ICU parameters (median [interquartile range])
Duration of mechanical ventilation, days 7 (4, 18) 5 (2, 9) 8 (4, 22) 0.001
Duration of sedation, days 6 (3, 12) 4 (2, 7) 7 (4, 13) 0.001
Maximum dose of midazolam in the first five days, mg/hour 3.4 (0, 5.4) 2 (0, 5.8) 3.6 (0.8, 5.4) 0.084
Maximum dose of propofol in the first five days, mg/hour 1 (1, 3.2) 0.8 (1, 3.1) 1 (1, 3.2) 0.866
Maximum dose of fentanyl in the first five days, mg/hour 1.6 (0, 2.4) 1.2 (0, 2.4) 1.6 (0, 2.4) 0.516
Maximum dose of morphine in the first five days, mg/hour 1 (0.5, 1.5) 1 (1, 1.5) 0.5 (0. 6,1) 0.044
Maximum dose of remifentanil in the first five days, mg/hour 0.1 (0, 0.2) 0.07 (0, 0.2) 0.1 (0, 0.2) 0.081
Maximum dose of dobutamine in the first five days, μg/kg/min 2.2 (0, 5.3) 1.4 (0, 8) 2.8 (0, 5.8) 0.038
Maximum dose of norepinephrine in the first five days, μg/kg/min 0.1 (0, 0.21) 0.07 (0, 0.15) 0.1 (0, 0.22) 0.01