Table 8. Multivariable linear regression analysis showing the association between ln-cFGF23 as dependent variables and mineral metabolism parameters, inflammatory markers, and dialysis features, (n = 150).
Multivariable | ln-cFGF23 | ||
---|---|---|---|
Variable | Beta¶ | 95% IC | P |
Model 1 | |||
ln-CRP a | 0.35 | 0.34–0.69 | <0.001 |
P b | 0.50 | 0.32–0.52 | <0.001 |
Model 2 | |||
Age | -0.20 | -0.02—-0.07 | <0.001 |
Dialysis Vintage c | 0.23 | 0.003–0.01 | <0.001 |
ln-CRP a | 0.37 | 0.37–0.70 | <0.001 |
P b | 0.44 | 0.27–0.46 | <0.001 |
Model 3 | |||
ln-CRP a | 0.35 | 0.34–0.69 | <0.001 |
P b | 0.50 | 0.32–0.52 | <0.001 |
a hs-CRP, C Reactive Protein
b P, Serum Phosphate
c Dialysis vintage, time since the initiation of dialysis.
Model 1: adjusted for serum phosphate, ionized serum calcium, and hs-CRP. (R2 = 0.46)
Model 2: adjusted for model 1 plus age, dialysis vintage, serum ferritin, iPTH, ferritin, 25 (OH) D, and 1,25 (OH) 2D. (R2 = 0.54)
Model 3: adjusted for model 1 plus calcium dialysate, the use of calcium-based binders, calcium-free binders, paricalcitol, cinacalcet and erythropoietin (R2 = 0.46)
¶ Standardized regression coefficients