Table 2. Reference reader signal ratings vs pathology.
| CJD (all types)a n (%) |
Not CJDb n (%) |
p value | vCJD n (%) |
sCJD n (%) |
p value | |
|---|---|---|---|---|---|---|
| n | 118 | 82 | 32 | 75 | ||
| Whole brain | 68 (57.6) | 44 (53.7) | 11 (34.4) | 47 (62.7) | ||
| Correctly identified by neuroradiologist | 89 (75.4) | 56 (68.3) | 20 (62.5) | 28 (37.3) | ||
| Brain atrophy | 13 (11.0) | 31 (37.8) | <0.0001 | 0 (0.0) | 11 (14.7) | 0.032 |
| White matter hyperintensities | 16 (13.6) | 39 (47.6) | <0.0001 | 0 (0.0) | 15 (20.0) | 0.005 |
| Caudate nucleus signal | ||||||
| Bright on T2 | 60 (50.9) | 11 (13.4) | <0.0001 | 16 (50.0) | 39 (52.0) | 1.000 |
| Bright or possibly bright on T2 | 85 (72.0) | 20 (24.4) | <0.0001 | 24 (75.0) | 54 (72.0) | 0.816 |
| Bright on PD | 107 (90.7) | 73 (89.0) | 0.812 | 31 (96.9) | 68 (90.7) | 0.431 |
| Bright or possibly bright on PD | 111 (94.1) | 76 (92.7) | 0.774 | 32 (100.0) | 70 (93.3) | 0.319 |
| Lentiform nucleus signal | ||||||
| Bright on T2 | 69 (58.5) | 14 (17.1) | <0.0001 | 20 (62.5) | 43 (57.3) | 0.672 |
| Bright or possibly bright on T2 | 95 (80.5) | 28 (34.2) | <0.0001 | 29 (90.6) | 58 (77.3) | 0.174 |
| Bright on PD | 105 (89.0) | 69 (84.2) | 0.393 | 27 (84.4) | 69 (92.0) | 0.299 |
| Bright or possibly bright on PD | 112 (94.9) | 75 (91.5) | 0.388 | 31 (96.9) | 71 (94.7) | 1.000 |
| Pulvinar signal | ||||||
| Bright on T2 | 38 (32.2) | 6 (7.3) | <0.0001 | 15 (46.9) | 19 (25.3) | 0.041 |
| Bright or possibly bright on T2 | 53 (44.9) | 9 (11.0) | <0.0001 | 20 (62.5) | 28 (37.3) | 0.020 |
| Bright on PD | 89 (75.4) | 50 (61.0) | 0.042 | 30 (93.8) | 54 (72.0) | 0.011 |
| Bright or possibly bright on PD | 101 (85.6) | 57 (69.5) | 0.008 | 31 (96.9) | 61 (81.3) | 0.036 |
| Pulvinar sign | ||||||
| Present on T2 | 8 (9.8) | 3 (2.5) | 0.530 | 6 (18.8) | 2 (2.7) | 0.009 |
| Present or pulvinar signal same as putamen on T2 | 49 (41.5) | 17 (20.7) | 0.002 | 20 (62.5) | 25 (33.3) | 0.010 |
| Present on PD | 10 (8.5) | 3 (3.7) | 0.246 | 8 (25.0) | 2 (2.7) | 0.001 |
| Present or pulvinar signal same as putamen on PD | 91 (77.1) | 49 (59.8) | 0.012 | 29 (90.6) | 55 (73.3) | 0.070 |
CJD = Creutzfeldt-Jakob Disease, vCJD = new variant Creutzfeldt-Jakob Disease, sCJD = sporadic Creutzfeldt-Jakob Disease, PD = proton density
Tests: Fisher’s exact 2 sided
a There were four cases of familial and seven cases of iatrogenic CJD included in the cohort
b Six non-CJD cases do not have age at death data