Table 3. Logistic regression models.

	CJD compared to not CJDa				vCJD compared to not vCJDb				sCJD compared to not sCJDc
		95% confidence interval				95% confidence interval				95% confidence interval
Variable	Odds ratio	Lower	Upper	p value	Odds ratio	Lower	Upper	p value	Odds ratio	Lower	Upper	p value
Age at death	1.102	0.905	1.340	0.334	0.420	0.310	0.570	<0.0001	2.662	1.954	3.625	<0.0001
Disease duration	1.129	1.071	1.191	<0.0001	1.103	1.049	1.161	<0.0001	1.071	1.024	1.119	0.002
Brain atrophyd	0.255	0.091	0.713	0.009	-	-	-	-	0.360	0.130	0.992	0.048
White matter signal changed	0.260	0.103	0.658	0.004	-	-	-	-	0.326	0.124	0.858	0.024
Bright or possibly bright caudate on T2	7.854	3.656	16.874	<0.0001	3.325	0.958	11.536	0.058	7.421	3.292	16.731	<0.0001
Pulvinar signd	3.306	0.674	16.207	0.140	-	-	-	-	0.729	0.115	4.605	0.737

CJD = Creutzfeldt-Jakob disease, vCJD = variant CJD, sCJD = sporadic CJD

^a Area under the curve = 0.881 (95% confidence interval 0.831–0.931), p-value <0.0001.

^b Area under the curve = 0.950 (95% confidence interval 0.921–0.978), p-value <0.0001.

^c Area under the curve = 0.860 (95% confidence interval 0.809–0.911), p-value <0.0001.

^d These variables were excluded from the model of vCJD compared to not vCJD due to lack of data (see also S1 Table)