Table 4. Misdiagnoses.
| Cases of CJD | Cases of non-CJD | |||||
|---|---|---|---|---|---|---|
| Correctly identified CJD (n = 89) n (%) |
Missed CJD (n = 29) n (%) |
p value | Correctly identified not CJD (n = 56) n (%) |
Overcalled CJD (n = 26) n (%) |
p value | |
| Whole brains | 54 (60.7) | 14 (48.3) | 0.282 | 31 (55.6) | 13 (50.0) | 0.812 |
| Scanner 1 (1.0 tesla) | 49 (55.1) | 18 (62.1) | 0.258 | 36 (64.3) | 11 (42.3) | 0.032 |
| Scanner 2 (2.0 tesla) | 12 (13.5) | 6 (20.7) | 8 (14.3) | 2 (7.7) | ||
| Scanner 3 (1.5 tesla) | 28 (31.5) | 5 (17.2) | 12 (21.4) | 13 (50.0) | ||
| Mean age at death in years (SD) | 52 (20) | 57 (21) | 0.246 | 65 (20) | 55 (25) | 0.053 |
| Mean disease duration in months (SD) | 9 (7) | 13 (12) | 0.012 | 3 (11) | 3 (7) | 0.699 |
| Brain atrophy | 6 (6.7) | 7 (24.1) | 0.016 | 21 (37.5) | 10 (38.5) | 1.000 |
| White matter hyperintensities | 9 (10.1) | 7 (24.1) | 0.067 | 31 (55.4) | 8 (30.8) | 0.057 |
| Caudate nucleus signal | ||||||
| Bright on T2 | 57 (64.1) | 3 (10.4) | <0.0001 | 0 (0.0) | 11 (42.3) | <0.0001 |
| Bright or possibly bright on T2 | 76 (85.4) | 9 (31.0) | <0.0001 | 5 (8.9) | 15 (57.7) | <0.0001 |
| Bright on PD | 87 (97.8) | 20 (69.0) | <0.0001 | 47 (83.9) | 26 (100.0) | 0.051 |
| Bright or possibly bright on PD | 88 (98.9) | 23 (79.3) | 0.001 | 50 (89.3) | 26 (100.0) | 0.170 |
| Lentiform nucleus signal | ||||||
| Bright on T2 | 65 (73.0) | 4 (13.8) | <0.0001 | 1 (1.8) | 13 (50.0) | <0.0001 |
| Bright or possibly bright on T2 | 85 (95.5) | 10 (34.5) | <0.0001 | 10 (17.9) | 18 (69.2) | <0.0001 |
| Bright on PD | 83 (93.3) | 22 (75.9) | 0.016 | 45 (80.4) | 24 (92.3) | 0.209 |
| Bright or possibly bright on PD | 88 (98.9) | 24 (82.8) | 0.003 | 50 (89.3) | 25 (96.2) | 0.422 |
| Pulvinar signal | ||||||
| Bright on T2 | 37 (41.6) | 1 (3.5) | <0.0001 | 1 (1.8) | 5 (19.2) | 0.011 |
| Bright or possibly bright on T2 | 49 (55.1) | 4 (13.8) | <0.0001 | 1 (1.8) | 8 (30.8) | <0.0001 |
| Bright on PD | 75 (84.3) | 14 (48.3) | <0.0001 | 27 (48.2) | 23 (88.5) | 0.001 |
| Bright or possibly bright on PD | 79 (88.8) | 22 (75.9) | 0.125 | 34 (60.7) | 23 (88.5) | 0.011 |
| Pulvinar sign | ||||||
| Present on T2 | 6 (6.7) | 2 (7.0) | 1.000 | 2 (3.6) | 1 (3.9) | 1.000 |
| Present or same signal as putamen on T2 | 42 (47.2) | 7 (24.1) | 0.032 | 9 (16.1) | 8 (30.8) | 0.150 |
| Present on PD | 8 (9.0) | 2 (6.9) | 1.000 | 2 (3.6) | 1 (3.9) | 1.000 |
| Present or same signal as putamen on PD | 72 (80.9) | 19 (65.5) | 0.125 | 27 (48.2) | 22 (84.6) | 0.002 |
CJD = Creutzfeldt-Jakob disease, SD = standard deviation, PD = proton density