Table 1. Immunasation schedule for live S. mansoni cercaria infection groups.
Groups: n = 5–8 | Infection | PZQ 1 | PZQ 2 | Vaccine 1 | Vaccine 2 | Sampling | |
---|---|---|---|---|---|---|---|
Week | 0 | 8 | 8.5 | 10 | 14 | 16 | |
Experiment 1 | MVA+Gp140 | - | - | - | ✓ | ✓ | ✓ |
Sm+MVA+Gp140 | ✓ | - | - | ✓ | ✓ | ✓ | |
Sm+PZQ+MVA+Gp140 | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | |
Sm+PZQ | ✓ | ✓ | ✓ | - | - | ✓ | |
Sm | ✓ | - | - | - | - | ✓ | |
Naïve | - | - | - | - | - | ✓ | |
Experiment 2 | DNA+MVA | - | - | - | ✓ | ✓ | ✓ |
Sm+DNA+MVA | ✓ | - | - | ✓ | ✓ | ✓ | |
Sm+PZQ+DNA+MVA | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | |
Sm+PZQ | ✓ | ✓ | ✓ | - | - | ✓ | |
Sm | ✓ | - | - | - | - | ✓ | |
Naïve | - | - | - | - | - | ✓ |