Figure 4.

Loss of ASL Leads to Dysregulation of Transcriptome in Human Endothelial Cells

(A) Heatmap showing hierarchical clustering of the top dysregulated genes in siASL-transfected HAECs.

(B) Histogram of genes that are differentially expressed in siControl- versus siASL-transfected HAECs.

(C) IPA analysis of top dysregulated pathways in ASL-deficient HAECs.

(D) IPA upstream regulator analysis showing genes predicted to be activated or inhibited in ASL-deficient HAECs based on the calculation of the activation Z-score.

(E) Working model of how ASL deficiency in endothelial cells leads to the development of hypertension.