Table 1. Catalytic Activities of DERAm and Its Y259F Mutant Using dR5P as a Substrate.
| DERA variant | kcat (s–1) | KM (mM) | kcat/KM (s–1 M–1) |
|---|---|---|---|
| DERAm | 19.0 ± 1.0 | 0.31 ± 0.01 | (6.1 ± 0.1) × 104 |
| DERAm Y259F | 0.20 ± 0.05 | 0.16 ± 0.01 | (1.3 ± 0.3) × 103 |
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