Table 5.

Daily dosage scheme of LCM and other AEDs at the time of discontinuation and the reasons for discontinuing LCM are shown

No.	Patient no.	Gender	Age (years)	Etiology	Discontinuation reason	Follow-up (months)	Lacosamide dose (mg)	Other AED, dosage (mg)
1	2	M	32	Birth related and/or genetica	Behavioral disorder	1b	300	LEV3,000, OXC900
2	7	M	44	Birth related and/or genetica	GI intolerance	6	300	OXC1,200
3	12	F	34	Brain tumor	Nausea/vomitingc	3	300	LAM300, CRB1,200
4	15	M	36	Birth related and/or genetica	Behavioral disorder	1b	400	LEV3,000
5	16	F	22	Mesial temporal sclerosis	Lack of efficacy	27	400	ZNS300, PHN300
6	22	M	19	Birth related and/or genetica	Behavioral disorder	1b	400	LEV2,000, PHN300
7	23	F	37	Brain tumor	Lack of efficacy	16	200	VAL1,500, PHN300
8	27	F	25	Cortical dysplasia	Pregnancy	37	400	LEV3,000, ZNS200
9	30	M	28	Birth related and/or genetica	Behavioral disorder	1b	350	LEV2,000, VAL1,500, OXC600
10	31	M	20	Meningitis sequelae	Palpitation	1	300	LAM300, PHN300
11	35	M	36	Birth related and/or genetica	Nausea/vomiting	3	300	LEV2,000, VAL2,000, LAM200
12	45	F	50	Birth related and/or genetica	Behavioral disorder	1b	200	LEV2,000, VAL1,000
13	46	F	16	Birth related and/or genetica	Lack of efficacy	34	300	LAM300, OXC1,200, VAL2,000, ZNS200
14	49	M	21	Post-traumatic	Nausea/vomiting	1	300	LAM400, CRB1,200
15	51	F	20	Birth related and/or genetica	Behavioral disorder	1b	300	LEV1,500
16	54	F	22	Birth related and/or genetica	Lack of efficacy	2	200	CRB1,200, ZNS200
17	67	F	16	Birth related and/or genetica	Allergic reaction	2	300	LAM200, OXC1,200
18	69	M	29	Birth related and/or genetica	Palpitation	4	400	LEV3,000, VAL3,000, CRB1,200
19	75	M	33	Mesial temporal sclerosis	Suicidal thoughts	10	300	LEV2,000, PHN200
20	77	F	27	Post-traumatic	Behavioral disorder	1b	300	LEV2,000, OXC1,200
21	78	M	52	Brain tumor	Lack of efficacy	28	300	LEV3,000, CRB1,000
22	83	F	43	Birth related and/or genetica	Palpitation	2	400	LAM350, PHN400
23	86	F	28	Post-traumatic	Lack of efficacy	19	300	LEV2,000
24	91	M	52	Brain tumor	Lack of efficacy	26	300	LEV1,000, CRB400
25	92	F	18	Birth related and/or genetica	Nausea/vomitingd	1	300	VAL750, CRB300
26	113	F	29	Mesial temporal sclerosis	Nausea/vomitingc	1	200	VAL1,500, OXC1,200
27	117	F	18	Birth related and/or genetica	Rash	11	400	LEV3,000, LAM300, CRB600, ZNS200
28	124	F	58	Post-traumatic	Fatigue	30	300	LEV3,000, CRB400
29	128	M	36	Brain tumor	Nausea	4	200	LEV1,500, PHN300
30	129	F	57	Cerebrovascular disease	Nausea/vomiting	2	300	LEV3,000, OXC900
31	136	M	27	Birth related and/or genetic	Lack of efficacy	25	300	LEV1,000, CRB1,200, VAL1,000

Notes:

^aPresumed birth-related complications and/or genetically inherited diseases.

^bSymptoms appeared in the first 2 weeks.

^cAccompanied by vertiginous symptoms.

^dWeight loss was observed.

Abbreviations: AED, antiepileptic drug; CRB, carbamazepine; GI, gastrointestinal; LAM, lamotrigine; LCM, lacosamide; LEV, levetiracetam; OXC, oxcarbazepine; PHN, phenytoin; VAL, valproic acid; ZNS, zonisamide.