Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 Aug 2;10:2419–2428. doi: 10.2147/CMAR.S168723

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2018 Zhao et al. This work is published and licensed by Dove Medical Press Limited

The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

PMC Copyright notice

TMEM17 knockdown inhibited proliferation, colony formation, invasion, and migration of MCF-7 and MDA-MB-231 cells. (A) Interference efficiency in MCF-7 and MDA-MB-231 cell lines after TMEM17 was knocked down by siRNA. (B) MTT assay shows that TMEM17 interference significantly inhibited proliferation in MCF-7 (the fifth day, p<0.001) and MDA-MB-231 (the fifth day, p<0.001) cells. (C) Colony formation assays revealed that TMEM17 knockdown significantly decreased the number of colonies of MCF-7 (p=0.007) and MDA-MB-231 (p=0.011) cells. (D) Transwell analysis revealed that TMEM17 knockdown inhibited the invasion of MCF-7 (p=0.0025) and MDA-MB-231 (p=0.0037). (E) Wound assay revealed that TMEM17 silencing also inhibited the migration of MCF-7 (p=0.0363) and MDA-MB-231 cells (p=0.0044).

Abbreviations: siRNA, small interfering RNA; siNC, small interfering negative control.