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. 2018 Aug 2;10:2419–2428. doi: 10.2147/CMAR.S168723

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© 2018 Zhao et al. This work is published and licensed by Dove Medical Press Limited

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TMEM17 promoted the proliferation and invasion of cancer cells via activation of AKT/GSK3β signaling. (A) The AKT inhibitor LY294002 (10 μM) could inhibit the TMEM17-induced increase with p-AKT (Ser 473) and p-GSK3β (Ser 9), and downregulate active β-catenin and Snail, and then restore the expression of c-myc, cyclin D1, and E-cadherin. (B) MTT assay revealed that increased cell proliferation caused by TMEM17 was reversed by LY294002 (the fifth day, p<0.001). (C) Transwell assay revealed that the increased invasiveness caused by TMEM17 was also reversed by LY294002 (p=0.002).