Figure 3.
An elongated biaryl sulfonamide or a biaryl amine lack effect on the WT Shaker KV channel. (A) Representative current traces of the WT Shaker KV channel in control solution and after application of 30 µM glibenclamide. Holding voltage, −80 mV; test-step voltage, −35 mV. (B) G(V) curve for the cell shown in A. (C) Representative current traces of the WT Shaker KV channel in control solution and after application of 30 µM retigabine. Holding voltage, −80 mV; test-step voltage, −35 mV. (D) G(V) curve for the cell shown in C.