Table 1. Summary of electrophysiological parameters determined for TTXr sodium channels NaV1.9 and NaV1.8. Parameters were measured in DRGs isolated from NaV1.8- or NaV1.9-deficient mice in the presence of 500 nM TTX and at 10°C, 20°C, and 30°C.
| Channel | Peak current (pA) | Conductance (nS) | Integrated peak area (pA) | Inactivation time constant (ms) | Time to peak (ms) | ||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 10°C | 20°C | 30°C | FC | 10°C | 20°C | 30°C | FC | 10°C | 20°C | 30°C | FC | 20°C | 30°C | FC | 10°C | 20°C | 30°C | FC | |
| NaV1.9 | −585.8 ± 135.7 | −2,342.8 ± 448.7 | 4.0 | 8.3 ± 1.2 | 31.5 ± 8.1 | 3.8 | 4.9 ± 1.3 | 22.0 ± 6.8 | 4.5 | 31.0 ± 9.1 | 8.0 ± 1.2 | 3.9 | 40.7 ± 11.2 | 12.2 ± 1.9 | 3.5 ± 0.5 | 3.3, 3.5 | |||
| NaV1.8 | −2,120 ± 876.8 | −4,444.3 ± 1,275.6 | −7,147.6 ± 2,005.5 | 1.6 | 32.2 ± 13.7 | 68.6 ± 20.8 | 117.1 ± 35.8 | 1.7 | 9.7 ± 3.2 | 15.7 ± 4.9 | 13.8 ± 4.2 | 0.9 | 2.5 ± 0.3 | 0.9 ± 0.1 | 2.8 | 6.4 ± 0.3 | 2.9 ± 0.2 | 1.3 ± 0.1 | 2.2, 2.2 |
All recordings were made with CsCl in the pipette solution. FC, fold change comparing 30°C with 20°C.