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. 2018 Aug 6;215(8):2137–2155. doi: 10.1084/jem.20171066

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© 2018 Stolte et al.

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Figure 8. — ATSP-7041 synergizes with chemotherapy agents. (A–C) CI plots for the combination of ATSP-7041 with doxorubicin, etoposide, and vincristine after 3-d treatment of (A) TC32, (B) TC138, and (C) CHLA258 cells. (D) Western blots showing increased p53 protein levels in TC32 cells treat with combinations of ATSP-7041 and doxorubicin. Cells were treated at indicated concentrations for 2 d (ATSP, ATSP-7041; Doxo, doxorubicin). (E) Western blots showing increased p53 protein levels in TC32 cells treated with combinations of ATSP-7041 and etoposide. Cells were treated at the indicated concentrations for 2 d (ATSP, ATSP-7041; Eto, etoposide). (F) Western blots showing increased p53 protein levels in TC32 cells treated with combinations of ATSP-7041 and vincristine. Cells were treated at the indicated concentrations for 2 d (ATSP, ATSP-7041; Vinc, vincristine).