Table 1. Enriched gene sets within up-regulated in cycling HSCs derived from 5-FU–treated mice, as compared to quiescent HSCs derived from untreated mice.
| Gene set name | Systematic name | NES | P value | Q value |
|---|---|---|---|---|
| HALLMARK_E2F_TARGETS | M5925 | 1.84 | 0.042 | 0.016 |
| HALLMARK_NOTCH_SIGNALING | M5913 | 1.82 | <0.01 | 0.017 |
| HALLMARK_ESTROGEN_RESPONSE_LATE | M5907 | 1.81 | <0.01 | 0.018 |
| HALLMARK_MYC_TARGETS_V1 | M5926 | 1.79 | <0.01 | 0.018 |
| HALLMARK_COMPLEMENT | M5921 | 1.75 | <0.01 | 0.02 |
| HALLMARK_ALLOGRAFT_REJECTION | M5950 | 1.71 | <0.01 | 0.021 |
| HALLMARK_IL2_STAT5_SIGNALING | M5947 | 1.66 | <0.01 | 0.022 |
| HALLMARK_TGF_BETA_SIGNALING | M5896 | 1.66 | <0.01 | 0.022 |
| HALLMARK_PROTEIN_SECRETION | M5910 | 1.65 | <0.01 | 0.022 |
| HALLMARK_MYC_TARGETS_V2 | M5928 | 1.65 | <0.01 | 0.022 |
| HALLMARK_XENOBIOTIC_METABOLISM | M5928 | 1.59 | <0.01 | 0.036 |
| HALLMARK_APICAL_JUNCTION | M5934 | 1.51 | 0.021 | 0.056 |
| HALLMARK_APOPTOSIS | M5902 | 1.48 | 0.046 | 0.067 |
| HALLMARK_P53_PATHWAY | M5939 | 1.46 | <0.01 | 0.073 |
The transcriptome data of cycling and quiescent HSCs were subjected to GSEA, and the threshold was set at P value <0.05. The normalized enrichment score (NES) reflects the degree to which a gene set is overrepresented at the top or bottom of a ranked list of genes. Bold indicates the gene sets in which q < 005.